4 5 6 Physiology in Medicine : Understanding Dynamic Alveolar 7 Physiology to Minimize Ventilator Induced Lung Injury ( VILI ) 8 9 10
نویسندگان
چکیده
1 2 3 Physiology in Medicine Paper (PIMP) 4 5 6 Physiology in Medicine: Understanding Dynamic Alveolar 7 Physiology to Minimize Ventilator Induced Lung Injury (VILI) 8 9 10 Gary F .Nieman, Josh Satalin, Michaela Kollisch-Singule, Penny Andrews, Hani 11 Aiash, Nader M. Habashi, Louis A. Gatto. 12 13 14 15 16 17 18 19 Affiliations: 20 1. SUNY Upstate Medical University, Syracuse, NY 21 2. R Adams Shock Cowley Trauma Center, Baltimore, MD 22 3. Suez Canal University, Egypt 23 4. SUNY Cortland, Cortland, NY 24 25 26 27 28 Corresponding Author 29 Joshua Satalin 30 750 East Adams St 31 Syracuse, NY 13210 32 [email protected] 33 Articles in PresS. J Appl Physiol (April 6, 2017). doi:10.1152/japplphysiol.00123.2017
منابع مشابه
Therapeutic efficacy of human mesenchymal stromal cells in the repair of established ventilator-induced lung injury in the rat.
BACKGROUND Rodent mesenchymal stem/stromal cells (MSCs) enhance repair after ventilator-induced lung injury (VILI). We wished to determine the therapeutic potential of human MSCs (hMSCs) in repairing the rodent lung. METHODS In series 1, anesthetized rats underwent VILI (series 1A, n = 8 to 9 per group) or protective ventilation (series 1B, n = 4 per group). After VILI, they were randomized t...
متن کاملSphingolipids in Ventilator Induced Lung Injury: Role of Sphingosine-1-Phosphate Lyase
Mechanical ventilation (MV) performed in respiratory failure patients to maintain lung function leads to ventilator-induced lung injury (VILI). This study investigates the role of sphingolipids and sphingolipid metabolizing enzymes in VILI using a rodent model of VILI and alveolar epithelial cells subjected to cyclic stretch (CS). MV (0 PEEP (Positive End Expiratory Pressure), 30 mL/kg, 4 h) in...
متن کاملInflammation and matrix remodeling during repair of ventilator-induced lung injury.
High-pressure ventilation triggers different inflammatory and matrix remodeling responses within the lung. Although some of them may cause injury, the involvement of these mediators in repair is largely unknown. To identify mechanisms of repair after ventilator-induced lung injury (VILI), mice were randomly assigned to baseline conditions (no ventilation), injury [90 min of high-pressure ventil...
متن کاملMechanical induction of group V phospholipase A(2) causes lung inflammation and acute lung injury.
Ventilation at high tidal volume may cause lung inflammation and barrier dysfunction that culminates in ventilator-induced lung injury (VILI). However, the mechanisms by which mechanical stimulation triggers the inflammatory response have not been fully elucidated. This study tested the hypothesis that onset of VILI is triggered by activation of secretory group V phospholipase A(2) (gVPLA2) in ...
متن کاملAlveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.
In patients requiring mechanical ventilation for acute lung injury or acute respiratory distress syndrome (ARDS), tidal volume reduction decreases mortality, but the mechanisms of the protective effect have not been fully explored. To test the hypothesis that alveolar macrophage activation is an early and critical event in the initiation of ventilator-induced lung injury (VILI), rats were venti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017